Thomas Rupp

Managing Director

Thomas Rupp Consulting UG

Biography

Thomas Rupp is Managing Director at Thomas Rupp Consulting UG (GmbH).  Since 2013 Thomas offers independent CMC consulting services in the field of therapeutic Nucleic Acids. Besides regulatory CMC support for oligonucleotides and mRNA in early clinical developments, he specializes in technical workshops on oligonucleotide manufacturing; facility design for large scale GMP manufacturing; process development; process trouble shooting; and as communication interface between sponsors and CMO. Thomas is a globally renowned Subject Matter Expert (SME) for oligonucleotide manufacturing.  Thomas started his career in the research group of Nobel Laureate Prof. Dr. H. zur Hausen in 1985 at the German Cancer Research Centre (DKFZ) in Heidelberg, Germany, by setting-up the core-facility for oligonucleotide manufacturing and DNA sequencing. Between 1990 and 1993 he then enjoyed working for Brian Sproat at EMBL, Heidelberg, Germany developing a DNA synthesizer, co-developing a DNA sequencer and also developing new DNA and RNA manufacturing processes, followed by one year in cancer research at Loyola University, Chicago, IL.
In 1994 he entered the world of therapeutic oligonucleotides by joining Innovir GmbH, Göttingen, Germany, and moved successively in 1997 to Berlin, Germany to set up the Spiegelmer production lab at Noxxon Pharma AG. Between 2002 and 2010 Thomas worked at GE Healthcare as Global Application Specialist for all oligonucleotide related products. In April 2010 Thomas joined the GMP Production Department of Girindus AG as internal SME and kept this position until Girindus was taken over by Nitto Denko Avecia in early 2013.