University of Milano
Senior Scientist at Dino Ferrari Center, IRCCS Ca’ Granda Foundation, DePT Neurosciences, University of Milan, involved in the study of the pathogenesis and treatment of neurodegenerative disorders, particularly of motor neuron diseases (Spinal Muscular Atrophy (SMA), Spinal Muscular Atrophy with Respiratory Distress (SMARD1), Amyotrophic Lateral Sclerosis (ALS), Charcot Marie Tooth Type 2A (CMT2A)).
Since 2005, involved in neurodegenerative and stem cell research in the Neural Stem Cell Lab, where received her training as PhD of Molecular and Translational Medicine.
The most recent themes of research are the following:
1) Molecular mechanisms of neurodegenerative diseases
Study of mechanisms underlying motor neuron disease pathogenesis using in vitro patient specific induced pluripotent stem cells (iPSC), iPSC-derived motor neurons and iPSC-derived brain and spinal cord organoids and murine models of the motor neuron disease
2) Cell-mediated therapeutic strategies for neurodegenerative diseases
Study of stem cell applications as a therapy for SMA, ALS and SMARD1 in murine models
3) Gene therapy and molecular approaches as a therapy for neurodegenerative diseases Adenovirus associated serotype 9 and antisense oligonucleotides based therapies in in vitro and in vivo disease models