Gyros Protein Technologies
Gyros Protein Technologies provides enabling peptide synthesis and bioanalytical solutions, helping scientists in research through bioprocess applications. Our peptide synthesizers PurePep® Chorus, Symphony® X, PurePep® Sonata®+, and chemistries deliver uncompromising purity, flexibility and quality in less time. Sensitive, accurate and robust nanoliter-scale immunoassays for pharmacokinetics/pharmacodynamics, immunogenicity and quantitating bioprocess impurities are performed on our proprietary platforms Gyrolab® xPand and Gyrolab xPlore™. Peptide synthesis and bioanalytical solutions: accelerate your discovery, development and manufacturing of safer biotherapeutics. Gyros Protein Technologies is part of the Biopharmaceutical Division of Mesa Laboratories, Inc.
Advion Interchim Scientific
Over 50 years of experience in chromatography, purification, flash and prep LC instrumentation and three decades of experience in design and development of novel mass spectrometry systems and accessories for life sciences, research, and industry.
SepaChrom Core competence is the manufacturing and trading of High-Quality products for Chromatography.
Decades of experience of our team, allows SepaChrom to be a reference to Chromatographers at R&D department as well QC laboratories and Production.
Our commitment is to provide the Highest Technical Support that Chromatographers expect from their supplier.
Ypso-Facto provides software solutions and consulting services to disrupt the way pharmaceutical, chemical and biotechnological processes are developed and assessed.
With a complementary know-how in (bio)chemistry, process engineering and software development, we help life science industries to develop, optimize and secure efficient and innovative processes.
In order to address your challenges, the GPX® approach capitalizes on the Guess ability of different experts, the possibility of Predictive simulation and the use of experimental data.
AmbioPharm, Inc. is a full-service peptide manufacturing company headquartered at our North Augusta, South Carolina, USA cGMP production site. Our second cGMP facility in Shanghai, China, performs process development & optimization, and manufactures building blocks, raw materials, and custom peptides at very large scale. Both cGMP facilities are capable of handling any manufacturing scale required to produce bulk peptides to custom specifications using a wide range of skill sets in both solid and solution-phase chemistry. Our management team has over 100 years cumulative experience running pilot to commercial scale production. We also perform organic conjugations to small molecules, proteins, toxoids, antifungals, KLH, and PEG.
CSBio is a leading peptide and instrumentation manufacturing company based in Silicon Valley in Menlo Park, California.
For over 25 years, CSBio has been providing high quality custom peptides, cGMP peptides, and automated peptide synthesizers to the global biotech community. Our peptide products and instrumentation can be found in production laboratories and pharmaceutical companies worldwide.
We have state of the art cGMP manufacturing facilities to take you from tox studies through market commercialization, and we’ve recently launched a proven line of oligonucleotide synthesizers for small scale R&D to large scale manufacturing.
DuPont Life Sciences
From complicated separations for drug development and crop-to-table processing solutions to enabling protein-rich diets and innovative healthcare solutions, DuPont´s broad range of Life Science products improve the quality of life for humans, plants, and animals in our world. As a global market leader in adsorbents, chromatography resins, and ion exchange resins, DuPont Water Solutions offers a broad range of products designed for use in bioprocessing and drug synthesis. Whether it’s new advanced gene therapies or a conventional small molecule drug, DuPont has a wide range of polymeric purification resins to fit a multitude of applications. With a wellness optimized world at our core, our global research and development capabilities can address purification challenges in drug and diagnostics manufacturing now and in the future, resulting in better outcomes for patients and life science companies alike.
emp BIOTECH has been manufacturing high quality reagents for oligonucleotide synthesis since 2002. Starting with BMT activator, we have expanded our portfolio to include deblocking, oxidizer, capping, solvent mixtures and other specialty reagents. In addition, emp BIOTECH provides a full range of EZ Dry moisture traps, post-synthesis labeling, as well as columns and resins for oligo purification.
emp BIOTECH has four manufacturing facilities, two located in Berlin Buch and the other two dedicated reagent synthesis sites in Berlin-Tempelhof and Berlin-Adlershof.
Our facilities include:
– Industrial filling stations
– Small scale production up to 200 L drums (Berlin-Tempelhof)
– Larger scale production up to 1400 L drums (Berlin-Adlershof)
We work individually with each of our clients to assess and meet their individual quality requirements. We deliver on schedule and in the size and quantity agreed upon. Quality assurance, transparent operating procedures, and change control are all part of the way we work.
PolyPeptide Group AG and its consolidated subsidiaries (“PolyPeptide”) is a focused Contract Development & Manufacturing Organization (CDMO) for peptide- and oligonucleotide-based active pharmaceutical ingredients. By supporting its customers mainly in pharma and biotech, it contributes to the health of millions of patients across the world. PolyPeptide offers products and services from pre-clinical through to commercial stages, including generics. Its active custom projects pipeline reflects the opportunities from novel drug therapies in development to fight both widespread and rare diseases. Dating back to 1952, PolyPeptide today runs a global network of six cGMP-certified facilities in Europe, the U.S. and India. PolyPeptide Group AG’s shares (SIX: PPGN) are listed on SIX Swiss Exchange.
Sartorius Chromatography Equipment
Novasep Equipment Solutions Is Now Sartorius Chromatography Equipment (SCE).
From development through to industrial scaling, we provide a complementary range of cGMP equipment and services for purification.
Pharmaceutical and biopharmaceutical companies are facing major challenges today, with rising drug production costs as well as lower production volumes due to unpredictable demand.
We embed these requirements right from the start when designing our chromatography equipment, promoting optimal efficiency in development and manufacturing processes.
SCIEX helps scientists in pharma discovery, development and manufacturing to transform pipeline capacity and capability through the adoption of CE and LC-MS technologies. You benefit from innovative technology that makes complex workflows easier and more efficient, while delivering the utmost in data quality. Highly reliable instrumentation, with high sensitivity and dynamic range for a variety of analytical applications. Advanced software with automation to make data processing easier.
Teledyne ISCO solutions for drug discovery, manufacturing, and pharmaceutical applications include automated flash and preparative chromatography systems, focused-gradient generators, mass spectrometer-directed detection, high-throughput gram and kilogram-scale purification, and high-performance columns geared to reliable method development and repeatability in the purification of small molecules, peptides and other biopolymers.
Tosoh Bioscience is an acknowledged global leader in liquid chromatography with a focus on bioseparations. Our chromatography experts enable our biopharma partners to provide safe and efficient therapies against life-threatening diseases.
We offer a comprehensive line of chromatography instrumentation, media and (U)HPLC columns. These are used from R&D to manufacturing to characterize and purify therapeutic peptides, proteins and oligonucleotides at lab, pilot, and commercial scale.
Tosoh Bioscience is part of the Tosoh Group, a Japanese chemical and specialty products group with over 100 companies worldwide and a workforce of about 13000 people.
UFAG Laboratorien AG
As a GMP accredited and FDA certified contract laboratory in Switzerland, UFAG Laboratorien AG provides chemical, physical, physico-chemical and microbiological analyses for the Pharmaceutical, Biotech, and Medical Device Industries including QC of raw materials/products, method development/validation, stability studies, bioanalytical and biosimilar testing, for small and bio-molecules (e.g. oligonucleotides, mAB).
Vapourtec have been the leading manufacturer of world-class flow chemistry equipment since 2003. Their flow chemistry equipment has helped revolutionise scientific research, enabling and empowering scientists to explore new chemical pathways and applications. Manufactured at their headquarters in Suffolk, United Kingdom, their flow chemistry systems are trusted by academics, chemists and manufacturers around the world. Vapourtec have grown extensively through the quality of their products and commitment to excellent service, and with over 860 publications, proud to be the most frequently cited flow chemistry equipment supplier.
For over 20 years, Asymchem has been positioned and structured to act as a true partner for pharmaceutical and biotech companies world-wide by offering integrated solutions across all stages of drug development and into commercialization. Our oligonucleotide solutions provide clients with full services in drug substance, from process development through GMP manufacturing, and drug product, from preformulation development through fill-finish. Asymchem’s Chemical Macromolecule Division (CMMD) can support traditional peptides, pseudopeptides, peptide+linker, peptide-drug conjugates, polymer-drug conjugates, and other highly active peptide molecules.
Axolabs is the world’s leading Custom Research Organization (CRO) in the field of preclinical and clinical development of DNA-/RNA-based therapeutics and nucleic acid medicines. We are committed to providing high-end solutions and consultancy services for the development of innovative drugs.
Our expert team has 21+ years of experience in the development of oligonucleotide therapeutics and as member of LGC Group has access to an excellent infrastructure. We are well known, from big-pharma and biotech to academia and venture capital, for our profound knowledge, high quality standards and excellent research. Our broad range of services for therapeutic oligonucleotides and mRNAs covers bioinformatics, chemical synthesis of oligonucleotides, oligonucleotide conjugates and formulations, analytics, bioanalytics, in vitro and in vivo testing.
BioSpring is a world leading contract manufacturing organization (CMO) for synthetic nucleic acids in the field of oligonucleotide-based commercial therapies, clinical therapeutic development, as well as diagnostics and R&D.
Since 1997, BioSpring provides high-quality products and services under cGMP to the pharmaceutical and biotech industry worldwide.
Located in Frankfurt, Germany, BioSpring’s cGMP-certified and FDA/EMA-inspected facilities offer manufacturing capacity of multiple hundred kilograms per year, including dedicated commercial manufacturing suits and state-of-the art commercial analytical laboratories.
Driven by technology and science, BioSpring’s team is developing innovative manufacturing processes and (bio)-analytical methods to contribute to the future of health in the field of oligonucleotide-based therapies, vaccines, and diagnostics.
Securing Life Sciences Supply Chains – where Chemistry meets Biology and Products meet Services, Biosynth is at the Edge of Innovation. With an unrivalled research product portfolio and end-to-end manufacturing services, we are science led and customer focused to solve problems and deliver key reagents across Complex Chemicals, Peptides and Key Biologics all from one trusted partner.
Euroapi is focused on reinventing active ingredient solutions to sustainably meet customers’ and patients’ needs around the world. We are a world leader in active pharmaceutical ingredients with some 200 products in our portfolio, offering a large span of technologies, while developing innovative molecules through our Contract Development and Manufacturing Organization (CDMO).
Taking action for health by enabling access to essential therapies inspires our 3,350 people every day. With strong research and development capabilities and six manufacturing sites all located in Europe, Euroapi ensures API manufacturing of the highest quality to supply customers in more than 80 countries.
Gilson, leader in fluidics, purification and sample management, manufactures since 1957 instrumentation and software enabling customers to purify and manipulate their samples. Our offer includes automated liquid handling products from Prep HPLC, SPE, and GPC Clean-up to our manual liquid handling products, as the world’s first adjustable volume pipette, PIPETMAN®.
Established in 1984, Neuland Laboratories is an end-to-end solutions provider for the pharmaceutical industry’s chemistry needs as a leading manufacturer of active pharmaceutical ingredients (APIs). Supported by three world-class US FDA and EU GMP compliant manufacturing facilities and complex chemistry capabilities, Neuland has become a trusted partner for innovators as well as generics.
Our Custom Manufacturing Solutions span the full range of the pharmaceutical industry’s chemistry requirements, from pre-IND through commercial manufacturing. We offer both small-scale clinical trial quantities and full commercial-scale supply with minimal tech transfer timelines. Our R&D facility is approved by the Department of Scientific and Industrial Research and inspected by the USFDA without any observations. The facility houses development labs, analytical labs, a kilo lab for scale-up and dedicated lab for peptides.
The company is headquartered in Hyderabad, India and the manufacturing and research facilities are situated near Hyderabad. Neuland is reliable manufacturing and development partner to customers in over 80 countries across US, Europe, Japan, APAC, India, MENA and LATAM.
Olon is one of the largest developers and manufacturers supplying APIs to industries worldwide to both Generic and CDMO market.
With more than 230 APIs for the Generic market and 33 chemical intermediates (under CMO) is holder of about 155 active US DMFs and 69 granted CoS.
Headquartered in Rodano (Italy), Olon has 11 manufacturing facilities: 8 in Italy, 1 in Spain, 1 in USA and 1 in India, and 3 branch offices in Germany, USA, China.
The manufacturing sites are regularly inspected by FDA and the most important national and international Authorities, and audited by our partners and customers.
Quality Assistance is a leading European Contract Research Organisation providing the pharmaceutical industry with all the analytical services required by EMA and FDA regulations for the development and marketing of innovative human medicinal products.
With more than 40 years’ experience, Quality Assistance has become a leader in analytical sciences and holds a unique position on the market with all its laboratories on one site and 230 highly qualified professionals.
We assist our clients from candidate selection, through non-clinical and clinical studies, to marketing authorisation, using our state-of-the-art, product-dedicated expertise in analytical sciences.
We are a contract research organization specializing in complicated and highly modified oligonucleotide synthesis, commonly used for therapeutic, diagnostic and research application. The company is located in Research Triangle Park in Morrisville, NC, USA.
Thermo Fisher Scientific
Advances in nucleic acid therapeutics
Nucleic acid therapeutics are changing healthcare by delivering promising drugs that use new technologies and modes of action to treat disease. Several of these innovative medicines are being utilized to treat infectious diseases, protein and gene deficiencies, and many types of cancers. With more and more effort and resources being directed into this area, we may only be at the beginning stages of a revolution in medicine.
Solutions for nucleic acid therapeutic development
There are two classes of nucleic acid therapeutics: mRNA-based therapeutics or vaccines and synthetic oligonucleotide therapeutics. Learn more below about the products and technologies you’ll need as you make critical choices to successfully develop and manufacture these revolutionary
mRNA-based therapeutics and vaccines
mRNA based therapeutics and vaccines are produced biosynthetically using nucleotides, enzymes, and mRNA modification systems.
Synthetic oligonucleotide therapeutics
Synthetic oligonucleotide therapeutics are produced chemically using DNA or RNA phosphoramidites
WuXi TIDES, a leading Contract Research and Development Manufacturing Organization (CRDMO) platform, is an integral part of WuXi STA, a subsidiary of WuXi AppTec. WuXi TIDES offers our worldwide partners efficient, flexible, and high-quality solutions for the discovery, development and manufacturing of oligonucleotides, peptides and related synthetic conjugates (“TIDES” drugs).
IN COLLABORATION WITH
IN COLLABORATION WITH
University of Barcelona
The University of Barcelona is the most formidable public institution of higher education in Catalonia, catering to the needs of the greatest number of students and delivering the broadest and most comprehensive offering in higher educational courses. The UB is also the principal centre of university research in Spain and has become a European benchmark for research activity, both in terms of the number of research programmes it conducts and the excellence these have achieved.
Its own history closely tied to the history of Barcelona and of Catalonia, our university combines the values of tradition with its position as an institution dedicated to innovation and teaching excellence: a university that is as outward-looking and cosmopolitan as the city from which it takes its name.
IN COLLABORATION WITH
University of Milan
The University of Milan, founded in 1924, is a public institution that has a proactive role in science, technology and economics networks. It was one LERU co-founders and is the only Italian University to be a member of the organisation. The University of Milan is involved in several national and international research programs and has also strengthened its efforts to promote technology transfer, a growth area offering exciting new changes and challenges. The results of its research, attested to by an important quantity of scientific publications, have allowed it to obtain the top positions in the most authoritative international rankings. The research at the Department of Pharmaceutical Sciences covers a range of activities focused on the design, synthesis, development, and control of novel biologically active molecules, and of new pharmaceutical drug delivery systems, food supplements, cosmetics, biocides and medical devices. The goals are those of improving knowledge in the field of basic research, a major cultural investment to design a qualified research aimed at the discovery of novel drugs and able to boost an efficient technology transfer.
IN COLLABORATION WITH
Department of Chemistry “Giacomo Ciamician" Alma Mater Studiorum – University of Bologna
The Department of Chemistry “Giacomo Ciamician" is within the University a community of over 100 researchers who, thanks to the high skills in all areas of chemistry, has the mission of creating scientific culture through basic and applied research, its promotion and diffusion both through didactic activities and with a strong relationship of comparison and exchange with society and the business world.
The Department has a long tradition of excellence in teaching, research and technology transfer in all sectors of the Chemical Sciences.
IN COLLABORATION WITH
The Institute for Advanced Chemistry of Catalonia (IQAC) is an institute owned by the Spanish National Research Council (CSIC) located in Barcelona. It was created in 2007 with the mission to perform research of excellence in Chemical Sciences with the broad goal of improving the quality of life. The general strategy to achieve this mission involves the application of chemical approaches to address and solve societal challenges, mainly those related to human health, the sustainability of chemical processes and products, and the needs for novel materials for different applications. Since its establishment, IQAC has been in a permanent attitude to transfer its knowledge and technology results to the industrial sector.
The research developed at IQAC is organized around two main nodes: Biological Chemistry and Nanobiotechnology and it is facilitated by a number of Key Enabling Technologies. Considering the objectives pursued, many of the investigations carried out by the Research Groups at IQAC lie at the intersection between nodes.