Agenda

8:50 – 9:05

Welcome

Azalea room

9:05 – 09:50

Keynote Lecture
LNA Building Blocks for Therapeutic Oligonucleotides

Jesper Wengel
University of Southern Denmark

09:50 – 10:40

Workshop on Discovery
Oligonucleotide Drug Discovery and Optimization: Case Studies from 15 Years of LNA Drug Design

Christoph Rosenbohm
Roche Denmark

10:40 – 11:00

CMC Considerations for mRNA based Therapeutics

Jo-Anne Riley
Intertek

11:00 – 11:40

COFFEE – POSTERS & EXHIBITION

11:40 – 12:10

Tackling the Challenge of Delivery for Antisense Oligonucleotides

Suzan Hammond
University of Oxford

12:10 – 13:00

Workshop on Manufacturing

Thomas Rupp
Thomas Rupp Consulting

13:00 – 14:00

LUNCH – POSTERS & EXHIBITION

14:00 – 14:20

Pilot and Production Scale Oligonucleotide Synthesis: Overcoming the challenges of polystyrene resin through a novel synthesis method

Hanson Chang
CS BIO

14:20 – 15:10

Workshop on Analytical
Analytical Analysis of Oligonucleotide APIs

Ed Huber
Nitto Denko Avecia

15:10 – 15:40

Roundtable
Oligo Drug Development

Moderator:
Arthur Krieg
Kathryn Ackley

15:40 – 16:20

COFFEE – POSTERS & EXHIBITION

16:20 – 17:05

Keynote Lecture
Regulatory Challenges in Oligonucleotide Drug Development using the Example of BC 007, neutralizer of Pathogenic Autoantibodies against G Protein-Coupled Receptors for Autoimmune-Associated Heart Failure

Annekathrin Haberland
Berlin Cures

17:05 – 17:30

Market Overview: Developments of an Advancing Oligonucleotide Therapeutics Pipeline

Detlef Rethage
Rethage Advisors

17:30 – 19:00

NETWORKING COCKTAIL RECEPTION – POSTERS & EXHIBITION

20:00 – 22:30

NETWORKING DINNER @ La casa dei ciliegi (walking distance)

For registered attendees only

8:50 – 8:55

Welcome

Detlef Rethage
Kathryn Ackley

8:55 – 9:40

Keynote Lecture
Mechanisms and Therapeutic Applications of Immune Stimulatory CpG DNA

Arthur M. Krieg
Checkmate Pharmaceuticals

9:40 – 10:10

Targeting Dynamin 2 in Centronuclear Myopathies with Antisense Oligonucleotides: Pathogenesis and Therapies

Belinda Cowling
Dynacure SAS

10:10 – 10:40

CMC Challenges Associated with Oligonucleotide Products for Local Administration

Bianca Mathee
ProQR Therapeutics N.V.

10:40 – 11:00

Investigator Talks

Kathryn Ackley

11:00 – 11:40

COFFEE – POSTERS & EXHIBITION

11:40 – 12:10

Multitargeting Spherical Nucleic Acids: Advantages & Applications

Matthias Schroff
Exicure

12:10 – 12:30

Manufacturing and process control of modified double stranded oligonucleotides

Manuela Fichte
BioSpring

12:30 – 12:50

Challenges and Considerations in Designing a Large-Scale Solvent Facility for Oligos

Derek Levison
emp Biotech

12:50 – 14:00

LUNCH – POSTERS & EXHIBITION

14:00 – 15:00

Panel Discussion
CDMO News Flashlight

Moderator:
Detlef Rethage

15:00 – 15:30

Regulatory CMC Strategies for Addressing Recent Agency Questions for Clinical and Commercial Stage Oligonucleotides

Jennifer Franklin
Ionis Pharmaceuticals

15:30 – 16:00

Oligonucleotide Manufacturing Capacity of CMO’s. How Much is Enough?

Detlef Rethage
Rethage Advisors

16:00 – 16:15

Final Discussion & Symposium Conclusion

Detlef Rethage
Kathryn Ackley

8:50 – 9:05

Welcome

Azalea room

9:05 – 9:50

Keynote Lecture
Peptide Therapeutics Market Trends

Frank Otto Gombert
GPRS – Gombert Pharma Research Solutions

9:50 – 10:20

How to Manage Oral Bioavailability for Cyclic Peptides

Thomas Vorherr
Novartis

10:20 – 10:40

Biological Assays: Responding to Increasing Demands in the Release
of Peptide-Based APIs

Michael Postlethwaite
Bachem

10:40 – 11:00

Investigators Talks

Sara Pellegrino
University of Milan

11:00 – 11:40

COFFEE – POSTERS & EXHIBITION

Workshop on Manufacturing – Moderator: Fernando Albericio

11:40 – 12:10

Production of Peptide via Recombinant Approach. Advantages and Disadvantages from the Economic, Quality and Regulatory Point of View

Piera Fonte
Olon

12:10 – 12:40

Synthesis of Linaclotide Peptide as an Example of a Complex Peptide for Commercial Large Scale Production-Case Study for Small and Commercial Production

Daniel Bourgin
Dr. Reddy’s CPS

12:40 – 13:00

Manufacturing NeoAntigen Peptides: Requirements and Pragmatism

Trishul Shah
Polypeptide Group

13:00 – 14:00

LUNCH – POSTERS & EXHIBITION

14:00 – 14:20

Large Scale Peptide Production via Microwave

Giorgio Marini
CEM

14:20 – 14:40

Are All Resins in Fact the Same? Examining the Advances and Challenges in Peptide Purification and Solid Phase Peptide Synthesis.

Alessandra Basso
Purolite

14:40 – 15:00

Fmoc-Cys(Msbh) – A Sophisticated Building Block for Cysteine-Rich Peptides. A Journey from Discovery to Large Scale Production

Markus Weishaupt
Iris Biotech

15:00 – 15:20

Cost Effective Peptide Purification via ZEOsphere DRP Mixed-Mode Chromatography

Victoria Custodis
Zeochem

15:20 – 15:40

Rapid solution-phase synthetic approach AJIPHASE® for large scale manufacturing

Daisuke Takahashi
Ajinomoto

15:40 – 16:20

COFFEE – POSTERS & EXHIBITION

16:20 – 16:50

Overcoming Challenges to Effect Best Case Technology Transfer

Ewa Kowalska
Ipsen Manufacturing

16:50 – 17:20

Cyclic Peptides with Therapeutic Activity

Fernando Albericio
University of Barcelona

17:20 – 17:30

Investigators Talks

Sara Pellegrino
Chairman

17:30 – 19:00

Networking Cocktail Reception – POSTERS & EXHIBITION

20:00 – 22:30

Networking Dinner @ La casa dei ciliegi (walking distance)

For registered attendees only

8:50 – 8:55

Welcome

Fernando Albericio
Anna Maria Papini

8:55 – 9:40

Keynote Lecture
Radiolabelled Peptides for Cancer Imaging and Therapy: Past-Present-Future

Melpomeni Fani
University Hospital Basel

9:40 – 10:25

Keynote Lecture
Halogenation controls structures and functions of supramolecular peptide assemblies

Pierangelo Metrangolo
Politecnico of Milan

10:25 – 10:45

Challenges in Peptide & Oligonucleotide Formulation: An Integrated CDMO Perspective

Fabio Stevanon 
Umberto Romeo
CordenPharma

10:45 – 11:00

Investigators Talks

Sara Pellegrino
University of Milan

11:00 – 11:40

COFFEE – POSTERS & EXHIBITION

Workshop on Delivery – Moderator: Anna Maria Papini

11:40 – 12:10

Specific Glycosylation Techniques for Efficient Protein Therapeutics

Anna Maria Papini
University of Florence

12:10 – 12:40

Drug Delivery
Multimodal PSMA ligand for targeted photodynamic therapy of PSMA-expressing tumors

Dennis Lowik
Radboud University Nijmegen

12:40 – 13:10

Appropriate Screening for ADME Properties and Pseudo-Allergic Reactions Is Key to Success in Peptide Drug Discovery: a Case Study

Elisabetta Bianchi
IRBM

13:10 – 14:00

LUNCH – POSTERS & EXHIBITION

14:00 – 14:45

Regulatory Lecture

Speaker TBC

14:45 – 16:00

Panel and Q&A
Round Table Academy and Industry

Fernando Albericio, Anna Maria Papini, Sara Pellegrino, Silvana Cappelletti, Thomas Vorherr

16:00 – 16:15

Final Discussion & Investigators Conclusion

Fernando Albericio
Anna Maria Papini